Skin Damage, Hair Loss Resulting From Diet Can Be Reversed With Experimental Drug

Skin Damage, Hair Loss Resulting From Diet Can Be Reversed With Experimental Drug

Skin damage, hair loss resulting from diet can be reversed with experimental drug use, according to a new study which was conducted in mice. It shows that damage to Hair and skin in mice caused by Western-style diet — high in fats and cholesterol — was reversed using a drug.

A study by researchers from Johns Hopkins in Baltimore, Maryland found that fat and cholesterol-rich diet can lead to hair loss, skin inflammation, and hair whitening.

Their findings were recently published in the Nature journal Scientific Reports.

Subroto Chatterjee and colleagues from Johns Hopkins Medicine in Baltimore, MD, developed an experimental drug, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP). They hoped this drug would help reverse the negative effects of an unhealthful diet.

D-PDMP drives the production of “glycosphingolipids” (GSLs), a type of fats (lipids). They are part of the cell membrane and other cell types.

GSLs are essential for the development of the external skin layer as well as keratinocytes, the predominant cell type in the epidermis that performs the pigmentation, or coloring, of skin, hair, and eyes.

During the research, the team split the mice into two distinct groups where the first group was allocated a regular mouse diet and other was assigned a high-fat, high-cholesterol diet.

After a few weeks, the team found that mice that ate a Western-style diet had started hair and displayed hair whitening and skin lesions.

“Further research is needed, but our findings show promise for someday using the drug we developed for skin diseases such as psoriasis and wounds resulting from diabetes or plastic surgery,” stated Chatterjee.

Then the researcher fed D-PDMP in capsule form to mice. They found that the group of the mouse on a fatty diet began to regain their lost hair and initial hair color.




Marry Saunders

Marry Saunders is a seasoned journalist with nearly a decade under her belt. While studying journalism at the University of Wisconsin, Marry found a passion for finding local stories.  As a contributor to Roswell Gazette, Marry mostly covers human interest stories.

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